What is Polynucleotide treatment?


This new injectable anti-ageing treatments are the latest advances in regenerative medicine. Polynucleotides work on the cellular level to help repair tissue and improve skin health in the face and body.


Polynucleotides are fragments of DNA that are sourced from fish and mirror our own DNA.  When injected into our tissues they up-regulate our fibroblasts thus boosting collagen and elastin. This bio-remodelling restores skin tone, elasticity and provides an antioxidant and hydrating effect that results in skin that looks and feels healthier.


Polynucleotides injections benefit skin revitalisation to combat signs of ageing, acne, scarring, rehydration for dull skin, loose skin, alopecia, hyperpigmentation, stretch marks, and wrinkles. 


polynucleotide under eye treatment
Polynucleotide under eye
polynucleotide skin rejuvenation

Polynucleotides Frequently Asked Questions


  • Stimulate and increase collagen production
  • Long-lasting and efficiently repair the skin 
  • Deep skin hydration
  • Noticeable lift and tighten the skin
  • Restoration of skin texture and smoothness
  • Upgrade and refine cellular renewal
  • Enhance skin firmness and elasticity
  • Diminish acne scars and stretch marks
  • Can be used where filler cannot such as around puffy eyes
  • Do not change the facial shape 

They are similar in terms of the effects but in addition to providing hydration like hyaluronic acid skin boosters, polynucleotides communicate with our cells to make them produce collagen and elastin.


Polunucleotides can target areas such as the eyes, lips and forehead where skin boosters, such as Profhilo, cannot be used.

Polynucleotide treatment for under eye rejuvenation has become my gold standard. It is designed to address a range of under-eye concerns, from dark circles to dry skin and fine lines, in order to provide a refreshed and radiant appearance.


This treatment offers a range of benefits, from brightening and smoothing dark circles to improving the appearance of dry skin and reducing the appearance of crow’s feet. Unlike traditional fillers “tear trough” treatment which has its own complications, Polynucleotide under eye treatment encourages the body to restore the quality of its own skin, resulting in a more natural-looking under-eye area.

The results can be seen after the first session, typically three sessions are required for the initial treatment. Each session builds on the next and continues to work for around 12 weeks.  The results last between six months to a year, a maintenance treatment is required at six months.

The treatment requires three sessions, spaced out by two-four weeks. I apply local anaesthetic cream to the area prior to injecting, and then administer the product to the desired area of the face or neck. 


The procedure itself is quick, has minimal discomfort and is tolerated well by patients.

Polynucleotide treatments can be used alone as well as in combination with other treatments such as anti wrinkle treatment, Profhilo or dermal filler etc.


Polynucleotides are particularly good for dark circles, soft hollowing under the eye and addressing the crepey tissue around the eye.  The treatment is often used in combination with anti wrinkle treatment.

As with any injectable treatment, there are risks to be aware of. As the origin is fish, polynucleotides are not suitable for vegetarians, vegans or those with fish allergies.


It’s also not appropriate for use during pregnancy or while breastfeeding.  Otherwise the treatment is relatively safe due to the fact that you can inject it into any type of anatomy with careful technique, means that almost anyone is a candidate.


However when performing an aesthetic procedure a thorough medical history is taken prior to the treatment  to screen for any psychological disorders or red flags before any aesthetic ”

Most patients experience little to no downtime after Polynucleotide injections. Some may have mild redness, swelling, or bruising at the injection sites, but these typically resolve within a few days.

After Polynucleotide treatments, you can expect improved skin texture with reduced fine lines and wrinkles. The treatments also increase skin elasticity, making your complexion more resilient and youthful. This therapy rejuvenates the skin, resulting in a healthier, revitalised appearance.



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